Properties of Hyperthyroid Rat Myocardium

Properties of hyperthyroid rat myocardium.

HYPOVENTILATION PRIOR TO ISCHEMIA PRECONDITIONS RAT MYOCARDIUM

Repetitive episodes of brief regional ischemia have been shown to reduce the severity of life-threatening ventricular anhythrnias and infarct size that occur during prolonged occlusion of the coronary artery. This phenomenon is known as ischemic preconditioning. During studies in anesthetized, open chest Wistar rats, we accidentally observed that poorly ventilated animals had a reduced seve...

Myocardium of the Rat

Pulsed field gradient nuclear magnetic resonance methods combined with nuclear magnetic resonance imaging were used to determine the water diffusion anisotropy in perfused rat hearts at 37°C. It was found that the observed diffusion coefficient DaPP (apparent diffusion coefficient) depends on the orientation of the applied gradient g. When g is parallel to the epicardial surface, the observed d...

The hyperthyroid heart. An analysis of systolic and diastolic properties in single rat ventricular myocytes.

Single ventricular myocytes were isolated by collagenase digestion from the hearts of 6-8-month-old male Wistar rats in either the control (euthyroid) state or after 7 days of daily injection of 0.64 mg/kg thyroxine (hyperthyroid). Myocytes were field-stimulated from slack length, and contraction was measured with an inverted microscope-photodiode array-computer apparatus. The effect of pacing ...

Cerebral Ischemia/Reperfusion Injury in the Hyperthyroid Rat

Background: Hyperthyroidism as a risk factor for stroke is not conclusive. There are no definite data on the relationship between ischemic cerebrovascular injury and hyperthyroidism. This study was designed to define whether the outcomes of post-ischemic stroke injury are influenced by chronic hyperthyroidism. Methods: Two groups of hyperthyroid (HT) and control euthyroid rats of equal numbers ...